Biomimetic hydrogel-CNT network induced enhancement of fluid-structure interactions for ultrasensitive nanosensors

Ultrasensitive tumour-penetrating nanosensors of protease activity

The ability to identify cancer lesions with endogenous biomarkers is currently limited to tumours ~1 cm in diameter. We recently reported an exogenously administered tumour-penetrating nanosensor that sheds, in response to tumour-specific proteases, peptide fragments that can then be detected in the urine. Here, we report the optimization, informed by a pharmacokinetic mathematical model, of th...

Fluid Structure Interactions for Blast Wave Mitigation

Simplified Fluid-Structure Interactions for Hemodynamics

Computing blood flows in a closed vascular system by isolating one section for simulation creates difficulties due to the time-periodic structure of the flow and possible non-physical back flow in the simplified geometry. We propose some solutions in the context of a simplified fluid structure interaction on a fixed geometry but with pressure dependent normal velocities at the compliant walls. ...

Novel Hydrogel Actuator Based on Biomimetic Chemistry

Hydrogel actuators were prepared by combining ionoprinting technique with reversible metal ion coordination chemistry found in mussel adhesive proteins. Hydrogels were formulated with biomimetic dopamine moiety, which contains a catechol side chain that is capable of forming mono-, bis-, and tris-complexes with ferric (Fe 3+ ) ions with increasing pH. CatecholFe 3+ complexation increased local ...

Superhydrophobic Trans-scale Structure Using a Combination of a Silicon Microbowl and Cnt Forest for Biomimetic Architecture

A new method to fabricate the trans-scale structure of the micro-scale bowl and the nano-scale carbon nanotube (CNT) forest is presented. The new method mimics the natural structure of a superhydrophobic surface like a lotus leaf. The robust silicon microstructure (Si microbowl) and the subsequent CVD growth of CNT have successfully combined the nanoscale CNT forest on the Si microbowl for enha...